Li Grande Zombi is the major serpent spirit of worship among New Orleans Voodooists. In New Orleans Voodoo, snakes are not seen as symbols of evil as in the story of Adam and Eve. Snakes are considered to be the holders of intuitive knowledge—knowing that which cannot be spoken. Women often dance with serpents to represent the spiritual balance between the genders. Voodoo rituals in New Orleans almost always include a snake dance to celebrate the link to the ancient knowledge. The origin of Li Grande Zombi can be traced to the serpent deity Nzambi from Whydah in Africa. According to the Bantu Creation story, Nzambi is the Creator God:
Nzambi exists in everything and controls the universe through his appointed Spirits. In the beginning only Nzambi existed. When he was ready to create, millions and millions of pieces of matter swirled around him counterclockwise until Ngombe was born. Ngombe is the universe, the planets, the stars and all physical matter. Nzambi then created movement, and the matter that he had created began to change and drift apart. So, he decided to create a being that could traverse the universe and mediate between matter and space. Nzambi focused on a fixed point and gave life to a being who was simultaneously man and woman, a manifestation of the nature of Nzambi, called Exú-Aluvaiá.
Sources: The Voodoo Hoodoo Spellbook